Colace® (docusate sodium) is a stool softener.

Colace® Capsules, 50 mg, contain the following:

Active Ingredient:   contains 50 mg of docusate sodium.

Inactive Ingredients:   Polyethylene glycol 400, gelatin, glycerin, sorbitol, propylene glycol, FD&C Red No. 40, D&C Red No. 33.

Colace® Capsules, 100 mg, contain the following:

Active Ingredient:   contains 100 mg of docusate sodium.

Inactive Ingredients:   Polyethylene glycol 400, gelatin, glycerin, sorbitol, propylene glycol, methylparaben, titanium dioxide, FD&C Red No. 40, D&C Red No. 33, propylparaben, FD&C Yellow No. 6.

Colace® Liquid, 1%, contains the following:

Active Ingredient:   each mL contains 10 mg of docusate sodium.

Inactive Ingredients:   citric acid, D&C Red No. 33, methylparaben, poloxamer, polyethylene glycol, propylene glycol, propylparaben, sodium citrate, vanillin, and purified water.

Colace® Syrup, 20 mg/5 mL, contains the following:

Active Ingredient:   each 5 mL contains 20 mg of docusate sodium.

Inactive Ingredients:    alcohol (not more than 1%), citric acid, D&C Red No. 33, FD&C Red No. 40, flavor (natural), menthol, methylparaben, peppermint oil, poloxamer, polyethylene glycol, propylparaben, sodium citrate, sucrose, and purified water.

ACTIONS AND USES

Colace®, a surface-active agent, helps to keep stools soft for easy, natural passage and is not a stimulant laxative, thus, not habit forming. Useful in constipation due to hard stools, in painful anorectal conditions, in cardiac and other conditions in which maximum ease of passage is desirable to avoid difficult or painful defecation, and when peristaltic stimulants are contraindicated.

Note: When peristaltic stimulation is needed due to inadequate bowel motility, see Peri-Colace® (stimulant laxative and stool softener).

CONTRAINDICATIONS

There are no known contraindications to Colace®.

Do not use when abdominal pain, nausea, or vomiting are present, unless directed by a doctor.

As with any drug, pregnant or nursing women should seek the advice of a health professional before using this product.

SIDE EFFECTS

The incidence of side effects--none of a serious nature--is exceedingly small. Bitter taste, throat irritation, and nausea (primarily associated with the use of the syrup and liquid) are the main side effects reported. Rash has occurred.

ADMINISTRATION AND DOSAGE

Orally  --Suggested daily Dosage: Adults and older children: 50 to 200 mg Children 6 to 12: 40 to 120 mg Liquid.

Infants and children under 3 years of age:   As prescribed by physician.

Children 3 to 6 years of age:   2mL one to three times daily

For retention or flushing enemas:   Add 5 to 10mL (1 to 2 tsp) of COLACE® liquid to the enema fluid.

The higher doses are recommended for initial therapy. Dosage should be adjusted to individual response. The effect on stools is usually apparent 1 to 3 days after the first dose. Colace® liquid or syrup must be given in a 6 oz. to 8 oz. glass of milk or fruit juice or in infant' formula to prevent throat irritation. In enemas-- Add 5 to 10 mL Colace® liquid) to a retention or flushing enema.

HOW SUPPLIED

Colace® capsules, 50 mg

   NDC 54092-052-30 Bottles of 30

   NDC 54092-052-60 Bottles of 60

   NDC 54092-052-52 Cartons of 100

     single unit packs

   NDC 54092-052-11 Blister Pack of 10

Colace® capsules, 100 mg

   NDC 54092-053-30 Bottles of 30

   NDC 54092-053-60 Bottles of 60

   NDC 54092-053-02 Bottles of 250

   NDC 54092-053-10 Bottles of 1000

   NDC 54092-053-52 Cartons of 100

     single unit packs

   NDC 54092-053-11 Blister Pack of 10

Note:   Colace® capsules should be stored at controlled room temperature (59°-86°F or 15°-30°C)

Colace® liquid, 1% solution; 10 mg/mL (with calibrated dropper)

   NDC 54092-414-16 Bottles of 16 fl oz

   NDC 54092-414-30 Bottles of 30 mL

Colace® syrup, 20 mg/5-mL teaspoon; contains not more than 1% alcohol

   NDC 54092-415-08 Bottles of 8 fl oz

   NDC 54092-415-16 Bottles of 16 fl oz

Manufactured for

Roberts Laboratories Inc., a subsidiary of

ROBERTS PHARMACEUTICAL CORPORATION

Eatontown, NJ 07724 USA