Multi-symptom Pepto-Bismol contains bismuth subsalicylate and is the only leading OTC stomach remedy clinically proven effective for both upper and lower GI symptoms. Pepto-Bismol is in more households than any other stomach remedy, making it a convenient recommendation with a name your patients will know. It has been clinically proven in double-blind placebo-controlled trials for relief of upset stomach symptoms and diarrhea.

Each tablespoon (15 ml) of Pepto-Bismol Liquid contains 262 mg bismuth subsalicylate. Each tablespoonful of liquid contains a total of 130 mg non-aspirin salicylate. Pepto-Bismol liquid contains no sugar and is low in sodium (less than 5 mg/tablespoonful). Inactive ingredients: benzoic acid, D&C Red No. 22, D&C Red No. 28, flavor, magnesium aluminum silicate, methylcellulose, saccharin sodium, salicylic acid, sodium salicylate, sorbic acid and water.

Each Pepto-Bismol Tablet contains 262 mg bismuth subsalicylate. Each tablet contains a total of 102 mg non-aspirin salicylate (99 mg non-aspirin salicylate for Cherry). Pepto-Bismol tablets contain no sugar and are very low in sodium (less than 2 mg/tablet). Inactive ingredients include: adipic acid (in Cherry only), calcium carbonate, D&C Red No. 27, FD&C Red No. 40 (in Cherry only), flavors, magnesium stearate, mannitol, povidone, saccharin sodium and talc.

Each Pepto-Bismol Caplet contains 262 mg bismuth subsalicylate. Each caplet contains a total of 99 mg non-aspirin salicylate. Caplets contain no sugar and are low in sodium (less than 3 mg/caplet). Inactive ingredients include: calcium carbonate, D&C Red No. 27, magnesium stearate, mannitol, microcrystalline cellulose, polysorbate 80, povidone, silicon dioxide, and sodium starch glycolate.

INDICATIONS

Pepto-Bismol controls diarrhea within 24 hours, relieving associated abdominal cramps; soothes heartburn and indigestion without constipating; and relieves nausea and upset stomach.

ACTIONS

For upset stomach symptoms (i.e., indigestion, heartburn, nausea and fullness caused by over-indulgence), the active ingredient is believed to work via a topical effect on the stomach mucosa. For diarrhea, it is believed to work by several mechanisms in the gastrointestinal tract, including: 1) normalizing fluid movement via an antisecretory mechanism, 2) binding bacterial toxins and 3) antimicrobial activity.

Children and teenagers who have or are recovering from chicken pox or flu should not use this medicine to treat nausea or vomiting. If nausea or vomiting is present, patients are advised to consult a doctor because this could be an early sign of Reye syndrome, a rare but serious illness.

This product contains non-aspirin salicylates. If taken with aspirin and ringing in the ears occurs, discontinue use. This product does not contain aspirin, but should not be administered to those patients who have a known allergy to aspirin or non-aspirin salicylates as an adverse reaction may occur. Caution is advised in the administration to patients taking medication for anticoagulation, diabetes and gout.

If diarrhea is accompanied by a high fever or continues more than 2 days, patients are advised to consult a physician. As with any drug, caution is advised in the administration to pregnant or nursing women.

Keep all medicine out of the reach of children.

Note: This medication may cause a temporary and harmless darkening of the tongue and/or stool. Stool darkening should not be confused with melena.

OVERDOSAGE

In case of overdose, patients are advised to contact a physician or Poison Control Center. Emesis induced by ipecac syrup is indicated in large ingestions provided ipecac can be administered within one hour of ingestion. Activated charcoal should be administered after gastric emptying. Patients should be evaluated for signs and symptoms of salicylate toxicity.

DOSAGE AND ADMINISTRATION

Liquid: well before using.

Adults--      2 tablespoonsful

                  (1 dose cup, 30 ml)

Children (according to age)--

9-12 yrs.    1 tablespoonful

                  ( 1 / 2 dose cup, 15 ml)

6-9 yrs.      2 teaspoonsful

                  ( 1 / 3 dose cup, 10 ml)

3-6 yrs.      1 teaspoonful

                  ( 1 / 6 dose cup, 5 ml)

Repeat dosage every 1 / 2 to 1 hour, if needed, to a maximum of 8 doses in a 24-hour period. Drink plenty of clear fluids to help prevent dehydration which may accompany diarrhea.

For children under 3 years of age, consult a physician.

Tablets:

Adults--Two tablets

Children (according to age)--

9-12 yrs.    1 tablet

6-9 yrs.       2 / 3 tablet

3-6 yrs.       1 / 3 tablet

Chew or dissolve in mouth. Repeat every 1 / 2 to 1 hour as needed, to a maximum of 8 doses in a 24-hour period. Drink plenty of clear fluids to help prevent dehydration, which may accompany diarrhea. For children under 3 years of age, consult a physician.

Caplets:

Adults--Two caplets

Children (according to age)--

9-12 yrs.     1 caplet

6-9 yrs.       2 / 3 caplet

3-6 yrs.       1 / 3 caplet

Swallow caplet(s) with water, do not chew. Repeat every 1 / 2 to 1 hour as needed, to a maximum of 8 doses in a 24-hour period. Drink plenty of clear fluids to help prevent dehydration, which may accompany diarrhea. For children under 3 years of age, consult a physician.

HOW SUPPLIED

Pepto-Bismol Liquid is available in: 4, 8, 12, and 16 FL OZ bottles. Pepto-Bismol Tablets are pink, round, chewable tablets imprinted with a debossed triangle and "Pepto-Bismol" on one side. Tablets are available in: boxes of 30 and 48. Caplets are available in bottles of 24 and 40. Caplets are imprinted with "Pepto-Bismol" on one side.

PRODUCT PHOTO(S):

NOTE: These photos can be used only for identification by shape, color, and imprint. They do not depict actual or relative size.

The product samples shown here have been supplied by the manufacturer and reproduced in full color by PDR as a quick-reference identification aid. While every effort has been made to assure accurate reproduction, please remember that any visual identification should be considered preliminary. In cases of poisoning or suspected overdosage, the drug' identity should be verified by chemical analysis.

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